Proteintech

Eg5 Polyclonal Antibody

Eg5 Antibody in Immunocytochemistry (ICC/IF)

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Eg5 Antibody (23333-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using (Product # 23333-1-AP) (Eg5 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Eg5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Eg5 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

23333-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Eg5 Fusion Protein Ag18695 (707-1052 aa encoded by BC136474)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LTEDLKTIK QTHSQELCKL MNLWTERFCA LEEKCENIQK PLSSVQENIQ QKSKDIVNKM TFHSQKFCAD SDGFSQELRN FNQEGTKLVE ESVKHSDKLN GNLEKISQET EQRCESLNTR TVYFSEQWVS SLNEREQELH NLLEVVSQCC EASSSDITEK SDGRKAAHEK QHNIFLDQMT IDEDKLIAQN LELNETIKIG LTKLNCFLEQ DLKLDIPTGT TPQRKSYLYP STLVRTEPRE HLLDQLKRKQ PELLMMLNCS ENNKEETIPD VDVEEAVLGQ YTEEPLSQEP SVDAGVDCSS IGGVPFFQHK KSHGKDKENR GINTLERSKV EETTEHLVTK SRLPLRA (707-1052 aa encoded by BC136474)

Target Information

This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The oncogenic properties of the EWSR1::CREM fusion gene are associated with polyamine metabolism.

Scientific reports

Kaprio H,Siddiqui A,Saustila L,Heuser VD,Gardberg M

Sat Mar 25 00:00:00 UTC 2023

KIF11 is a potential prognostic biomarker and therapeutic target for adrenocortical carcinoma.

Translational andrology and urology

Zhou Y,Chen X,Li B,Li Y,Zhang B

Fri Apr 28 00:00:00 UTC 2023

Cyclovirobuxine D inhibits growth and progression of non‑small cell lung cancer cells by suppressing the KIF11‑CDC25C‑CDK1‑CyclinB1 G₂/M phase transition regulatory network and the NFκB/JNK signaling pathway.

International journal of oncology

Xue T,Chen Y,Xu J,Du W,Kong P,Zhang X

Mon May 01 00:00:00 UTC 2023

Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis.

Frontiers in pharmacology

Mengyan X,Kun D,Xinming J,Yutian W,Yongqian S

Sat Oct 01 00:00:00 UTC 2022

The therapeutic effect of KSP inhibitors in preclinical models of cholangiocarcinoma.

Cell death & disease

Shi Y,Cui X,Jiang T,Pan Y,Lin Y,Feng X,Ding Z,Yang C,Tan Y,Wang H,Dong L

Mon Sep 19 00:00:00 UTC 2022

The therapeutic effect of KSP inhibitors in preclinical models of cholangiocarcinoma.

Cell death & disease

Shi Y,Cui X,Jiang T,Pan Y,Lin Y,Feng X,Ding Z,Yang C,Tan Y,Wang H,Dong L

Mon Sep 19 00:00:00 UTC 2022

KIF11 promotes cell proliferation via ERBB2/PI3K/AKT signaling pathway in gallbladder cancer.

International journal of biological sciences

Wei D,Rui B,Qingquan F,Chen C,Ping HY,Xiaoling S,Hao W,Jun G

Fri Jan 14 00:00:00 UTC 2022

KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors.

Neuro-oncology advances

Terribas E,Fernández M,Mazuelas H,Fernández-Rodríguez J,Biayna J,Blanco I,Bernal G,Ramos-Oliver I,Thomas C,Guha R,Zhang X,Gel B,Romagosa C,Ferrer M,Lázaro C,Serra E

Wed Jul 01 00:00:00 UTC 2020

KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors.

Neuro-oncology advances

Terribas E,Fernández M,Mazuelas H,Fernández-Rodríguez J,Biayna J,Blanco I,Bernal G,Ramos-Oliver I,Thomas C,Guha R,Zhang X,Gel B,Romagosa C,Ferrer M,Lázaro C,Serra E

Wed Jul 01 00:00:00 UTC 2020

Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma.

American journal of translational research

Li X,Huang W,Huang W,Wei T,Zhu W,Chen G,Zhang J

Mon Sep 28 00:00:00 UTC 2020

Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA-30a in breast cancer.

Molecular carcinogenesis

Wang B,Yu J,Sun Z,Luh F,Lin D,Shen Y,Wang T,Zhang Q,Liu X

Sat Aug 01 00:00:00 UTC 2020

Development and validation of a five-gene model to predict postoperative brain metastasis in operable lung adenocarcinoma.

International journal of cancer

Fu F,Zhang Y,Gao Z,Zhao Y,Wen Z,Han H,Li Y,Chen H

Wed Jul 15 00:00:00 UTC 2020

Involvement of C-terminal truncation mutation of kinesin-5 in resistance to kinesin-5 inhibitor.

PloS one

Saeki E,Yasuhira S,Shibazaki M,Tada H,Doita M,Masuda T,Maesawa C

Tue May 21 00:00:00 UTC 2019

Involvement of C-terminal truncation mutation of kinesin-5 in resistance to kinesin-5 inhibitor.

PloS one

Saeki E,Yasuhira S,Shibazaki M,Tada H,Doita M,Masuda T,Maesawa C

Tue May 21 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: Kines; Kinesin-like protein 1; Kinesin-like protein KIF11; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5

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Gene Aliases: EG5; HKSP; KIF11; KNSL1; MCLMR; TRIP5

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UniProt ID: (Human) P52732

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Entrez Gene ID: (Human) 3832

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Function(s)

microtubule motor activity ATP binding microtubule binding ATP-dependent microtubule motor activity, plus-end-directed protein kinase binding protein complex binding microtubule binding motor protein

Process(es)

retrograde vesicle-mediated transport, Golgi to ER microtubule-based movement spindle organization mitotic spindle organization chromosome segregation mitotic nuclear division mitotic centrosome separation antigen processing and presentation of exogenous peptide antigen via MHC class II regulation of mitotic centrosome separation cell division mitotic spindle assembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Eg5 Polyclonal Antibody

Eg5 Antibody (23333-1-AP) in ICC/IF

Product Details

23333-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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