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Proteintech
Emerin Polyclonal Antibody
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Product Details
10351-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Emerin Fusion Protein Ag0236 (66-252 aa encoded by BC000738)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
75 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: STRGDADMY DLPKKEDALL YQSKGYNDDY YEESYFTTRT YGEPESAGPS RAVRQSVTSF PDADAFHHQV HDDDLLSSSE EECKDRERPM YGRDSAYQSI THYRPVSASR SSLDLSYYPT SSSTSFMSSS SSSSSWLTRR AIRPENRAPG AGLGQDRQVP LWGQLLLFLV FVIVLFFIYH FMQAEEGN (66-252 aa encoded by BC000738 )
Target Information
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EMD; Emerin; LEM domain containing 5
Gene Aliases: AW550900; EDMD; EMD; LEMD5; STA
UniProt ID: (Human) P50402, (Mouse) O08579
Entrez Gene ID: (Human) 2010, (Mouse) 13726
muscle contraction
muscle organ development
skeletal muscle cell differentiation
positive regulation of protein export from nucleus
negative regulation of fibroblast proliferation
regulation of canonical Wnt signaling pathway
cellular response to growth factor stimulus
nuclear membrane organization
negative regulation of canonical Wnt signaling pathway
amyloid fibril formation
negative regulation of catenin import into nucleus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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