This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: ASSYSFSDLN STRGDADMYD LPKKEDALLY QSKGYNDDYY EESYFTTRTY GEPESAGPSR AVRQSVTSFP DADAFHHQVH DDDLLSSSEE ECKDRERPMY GRDSACQSIT HY
Highest antigen sequence identity to the following orthologs: Mouse - 71%, Rat - 73%.
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Emerin; LEM domain containing 5
Gene Aliases: AW550900; EDMD; EMD; LEMD5; STA