Proteintech

Endoglin/CD105 Polyclonal Antibody

Endoglin/CD105 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

Endoglin/CD105 Antibody (10862-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 10862-1-AP (Endoglin/CD105 antibody) at dilution of 1:4000 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Endoglin/CD105 Antibody in Western Blot (WB)

Endoglin/CD105 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10862-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:2,000-1:8,000

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Flow Cytometry (Flow)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Bovine, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Endoglin/CD105 Fusion Protein Ag1287 (331-658 aa encoded by BC014271)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GGRLQTSPA PIQTTPPKDT CSPELLMSLI QTKCADDAMT LVLKKELVAH LKCTITGLTF WDPSCEAEDR GDKFVLRSAY SSCGMQVSAS MISNEAVVNI LSSSSPQRKK VHCLNMDSLS FQLGLYLSPH FLQASNTIEP GQQSFVQVRV SPSVSEFLLQ LDSCHLDLGP EGGTVELIQG RAAKGNCVSL LSPSPEGDPR FSFLLHFYTV PIPKTGTLSC TVALRPKTGS QDQEVHRTVF MRLNIISPDL SGCTSKGLVL PAVLGITFGA FLIGALLTAA LWYIYSHTRS PSKREPVVAV AAPASSESSS TNHSIGSTQS TPCSTSSMA (331-658 aa encoded by BC014271)

Target Information

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD105; CD105 antigen; Cell surface MJ7/18 antigen; Endoglin; ORW; transmembrane glycoprotein

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Gene Aliases: AI528660; AI662476; CD105; Edg; END; Endo; ENG; HHT1; ORW1; S-endoglin

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UniProt ID: (Human) P17813, (Mouse) Q63961

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Entrez Gene ID: (Human) 2022, (Mouse) 13805, (Rat) 497010

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Function(s)

transmembrane signaling receptor activity transforming growth factor beta receptor, cytoplasmic mediator activity type II transforming growth factor beta receptor binding protein binding galactose binding glycosaminoglycan binding type I transforming growth factor beta receptor binding BMP binding protein homodimerization activity activin binding transforming growth factor beta binding transforming growth factor beta-activated receptor activity transmembrane signal receptor

Process(es)

chronological cell aging patterning of blood vessels vasculogenesis positive regulation of protein phosphorylation heart looping sprouting angiogenesis endocardial cushion morphogenesis cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis cell migration involved in endocardial cushion formation regulation of transcription, DNA-templated cell adhesion negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation regulation of transforming growth factor beta receptor signaling pathway central nervous system vasculogenesis negative regulation of cell migration BMP signaling pathway positive regulation of BMP signaling pathway negative regulation of protein autophosphorylation dorsal aorta morphogenesis positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter smooth muscle tissue development artery morphogenesis venous blood vessel morphogenesis endocardial cushion to mesenchymal transition positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation negative regulation of transcription from RNA polymerase II promoter angiogenesis response to hypoxia negative regulation of endothelial cell proliferation positive regulation of systemic arterial blood pressure protein phosphorylation transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway heart development positive regulation of gene expression cell migration extracellular matrix disassembly positive regulation of collagen biosynthetic process intracellular signal transduction wound healing cell motility negative regulation of nitric-oxide synthase activity cell chemotaxis negative regulation of pathway-restricted SMAD protein phosphorylation extracellular matrix constituent secretion detection of hypoxia response to corticosteroid response to statin bone development cellular response to mechanical stimulus response to transforming growth factor beta

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Endoglin/CD105 Polyclonal Antibody

Endoglin/CD105 Antibody (10862-1-AP) in IHC (P)

Product Details

10862-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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