The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Big endothelin 1; Big endothelin-1; Big ET; Big ET 1; Big ET1; BigET; Endothelin-1; Et; ET-1; PPET1; Preproendothelin-1
Gene Aliases: ARCND3; EDN1; ET1; HDLCQ7; PPET1; QME
UniProt ID: (Human) P05305
Entrez Gene ID: (Human) 1906