|Immunohistochemistry (Paraffin) (IHC (P))||1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated Cys-S-Abu-SSWLDKE-Abu-VYF-Abu-HLDIIW|
|Storage buffer||whole serum|
|Contains||0.05% sodium azide|
IHC (P) analysis shows positive staining of endothelin-2 in human lung tissue.
Endothelins are endothelium-derived vasoconstrictor peptides. Endothelin 2, also known as ET-2, is a protein that in humans is encoded by the EDN2 gene. The secreted peptide (~2kD, 21 amino acids) is produced as a result of endothelin-2 precursor (~20 kD) processing and functions as a ligand for endothelin receptors which upon peptide binding modulates a wide array of cell signaling events. Diseases associated with endothelins include aortic disease and patent ductus arteriosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EDN 2; EDN-2; Endothelin 2; Endothelin-2; ET-2; ET2; PPET2; preproendothelin 2; Preproendothelin-2
Gene Aliases: EDN2; ET-2; ET2; PPET2
UniProt ID: (Human) P20800
Entrez Gene ID: (Human) 1907
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