PA1-24566 detects Endothelin B Receptor in Human samples.
PA1-24566 has been successfully used in immunohistochemistry (paraffin) procedures.
PA1-24566 immunogen corresponds to Synthetic peptide - KLH conjugated. Sequence identity/similarity to Mouse: 72/72%. Rat: 72/72%.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system.
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Protein Aliases: AU022549; Endothelin receptor non-selective type; endothelin receptor subtype B1; Endothelin receptor type B; ET-B; ET>B<; ETb; ETR-b; s; Sox10m1
Gene Aliases: ABCDS; EDNRB; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB; HSCR; HSCR2; WS4A
UniProt ID: (Human) P24530
Entrez Gene ID: (Human) 1910