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Invitrogen
Endothelin B Receptor Polyclonal Antibody
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 5
Endothelin B Receptor Antibody (PA5-28766) in WB
Knockdown of Endothelin B Receptor was achieved by transfecting Caco-2 with Endothelin B Receptor specific siRNAs (Silencer® select Product # s533982, s4468). Western blot analysis (Fig. a) was performed using 1% SDS from the Endothelin B Receptor knockdown cells (lane 3), non-specific scrambled siRNA transfected cells (lane 2) and untransfected cells (lane 1). The blots were probed with Endothelin B Recept... View More
Product Details
PA5-28766
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region within amino acids 378 and 442 of Human Endothelin B receptor
Conjugate
Form
Liquid
Concentration
0.52 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546242
Product Specific Information
Recommended positive controls: A375, Rat2.
Predicted reactivity: Mouse (100%), Rat (100%), Dog (100%), Pig (100%), Rabbit (100%), Chicken (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AU022549; endothelin B receptor; Endothelin receptor non-selective type; endothelin receptor subtype B1; Endothelin receptor type B; endothelin-B receptor; ET-B; Et-b receptor; Et-b-r; ET-BR; ET-RB; Etb receptor; Etb-svr; RP11-318G21.1
Gene Aliases: ABCDS; Ednra; EDNRB; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB; HSCR; HSCR2; WS4A
UniProt ID: (Human) P24530, (Rat) P21451
Entrez Gene ID: (Human) 1910, (Rat) 50672
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
positive regulation of protein phosphorylation
regulation of pH
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
peripheral nervous system development
posterior midgut development
aging
regulation of blood pressure
positive regulation of cell proliferation
negative regulation of neuron maturation
response to organic cyclic compound
vein smooth muscle contraction
sensory perception of pain
cGMP-mediated signaling
melanocyte differentiation
regulation of fever generation
negative regulation of cellular protein metabolic process
response to lipopolysaccharide
enteric smooth muscle cell differentiation
positive regulation of urine volume
positive regulation of renal sodium excretion
epithelial fluid transport
vasoconstriction
vasodilation
negative regulation of apoptotic process
pigmentation
developmental pigmentation
macrophage chemotaxis
response to pain
enteric nervous system development
regulation of epithelial cell proliferation
regulation of sensory perception of pain
positive regulation of penile erection
cellular response to lipopolysaccharide
endothelin receptor signaling pathway
cell surface receptor signaling pathway
negative regulation of adenylate cyclase activity
nervous system development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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