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Invitrogen

CD3/CD20 (Epcoritamab Biosimilar) Recombinant Human Monoclonal Antibody

View all (10) CD3/CD20 antibodies

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Product Details

MA5-42271

Applications
Tested Dilution
Publications

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Human / IgG1, kappa/IgG1, lambda

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Immunogen

Human CD3E;MS4A1/CD20

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.82 mg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911414

Product Specific Information

Endotoxin level < 0.01EU/µg by LAL method

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.

MA5-42271 is a chimeric antibody. The variable regions from one species have been grafted to the backbone of the other species.

Target Information

The CD3 antibody reacts with the intracytoplasmic portion of the CD3 antigen expressed by normal and neoplastic T-lymphocytes. It stains human T-lymphocytes in both cortex and medulla of the thymus and in peripheral lymphoid tissues. CD20 is a non-Ig differentiation antigen of B-lymphocytes and the expression of CD20 is restricted to normal and neoplastic B-lymphocytes, being absent from all other leukocytes and tissues. The CD3-CD20 cocktail reveals lymphoid architecture in neoplastic situations.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B-lymphocyte antigen CD20; B-lymphocyte cell-surface antigen B1; B-lymphocyte surface antigen B1; Bp35; CD20; CD20 antigen; CD20 receptor; CD3 antigen, delta subunit; CD3 delta; CD3-epsilon; CD3d; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3e; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3g; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains, subfamily A, member 1; OKT3, delta chain; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; unnamed protein product

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Gene Aliases: B1; Bp35; CD20; CD3-DELTA; CD3-GAMMA; CD3D; CD3DELTA; CD3E; CD3epsilon; CD3G; CD3GAMMA; CVID5; FMC7; IMD17; IMD18; IMD19; LEU-16; MS4A1; S7; T3D; T3E; T3G; TCRE

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UniProt ID: (Human) P04234, (Human) P07766, (Human) P09693, (Human) P11836

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Entrez Gene ID: (Human) 915, (Human) 916, (Human) 917, (Human) 931

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Function(s)
transmembrane signaling receptor activity protein binding identical protein binding SH3 domain binding protein kinase binding receptor signaling complex scaffold activity T cell receptor binding epidermal growth factor receptor binding immunoglobulin binding MHC class II protein complex binding
Process(es)
adaptive immune response immune system process cell surface receptor signaling pathway positive thymic T cell selection alpha-beta T cell activation T cell receptor signaling pathway establishment or maintenance of cell polarity protein transport T cell activation gamma-delta T cell activation protein-containing complex assembly regulation of lymphocyte apoptotic process store-operated calcium entry humoral immune response response to bacterium B cell differentiation B cell proliferation B cell activation B cell receptor signaling pathway protein tetramerization calcium ion import into cytosol positive regulation of calcium ion import across plasma membrane positive regulation of cell-matrix adhesion positive regulation of T cell anergy T cell anergy transmembrane receptor protein tyrosine kinase signaling pathway signal complex assembly G-protein coupled receptor signaling pathway smoothened signaling pathway regulation of signal transduction positive regulation of gene expression negative regulation of gene expression dendrite development calcium-mediated signaling cerebellum development T cell costimulation positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-4 production positive regulation of cell-cell adhesion mediated by integrin CD4-positive, alpha-beta T cell proliferation T cell proliferation positive regulation of T cell proliferation regulation of apoptotic process positive regulation of MAPK cascade negative thymic T cell selection negative regulation of smoothened signaling pathway lymphocyte activation positive regulation of calcium-mediated signaling positive regulation of T cell activation apoptotic signaling pathway positive regulation of CD4-positive, alpha-beta T cell proliferation
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