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EphA2 Polyclonal Antibody
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FIGURE: 1 / 4
EphA2 Antibody (BS-0485R) in IHC (P)
Formalin-fixed and paraffin-embedded rat brain labeled with Anti-EphA2/Eph receptor A2 Polyclonal Antibody, Unconjugated(bs-0485R) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated(bs-0295G-Cy3)used at 1:200 dilution for 40 minutes at 37°C.
Product Details
BS-0485R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human EphA2, amino acids 901-976.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ephrin receptor EphA2; Ephrin type-A receptor 2; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; Tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor MPK-5; Tyrosine-protein kinase receptor SEK-2; unnamed protein product
Gene Aliases: ARCC2; AW545284; CTPA; CTPP1; CTRCT6; ECK; EPHA2; Myk2; Sek-2; Sek2
UniProt ID: (Human) P29317, (Mouse) Q03145
Entrez Gene ID: (Human) 1969, (Mouse) 13836, (Rat) 366492
nucleotide binding
virus receptor activity
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
ephrin receptor activity
protein binding
ATP binding
kinase activity
transferase activity
growth factor binding
cadherin binding
molecular function activator activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
skeletal system development
angiogenesis
blood vessel development
vasculogenesis
osteoblast differentiation
negative regulation of cytokine production
blood vessel endothelial cell proliferation involved in sprouting angiogenesis
apoptotic process
response to stress
inflammatory response
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of lamellipodium assembly
notochord formation
cell migration
negative regulation of angiogenesis
neural tube development
central nervous system neuron differentiation
cell differentiation
regulation of cell adhesion
keratinocyte differentiation
osteoclast differentiation
regulation of cell migration
positive regulation of cell migration
epithelial cell differentiation
negative regulation of chemokine production
mammary gland epithelial cell proliferation
regulation of cell adhesion mediated by integrin
post-anal tail morphogenesis
regulation of blood vessel endothelial cell migration
regulation of angiogenesis
cAMP metabolic process
viral entry into host cell
bone remodeling
ephrin receptor signaling pathway
axial mesoderm formation
animal organ development
blood vessel morphogenesis
notochord morphogenesis
cell motility
defense response to Gram-positive bacterium
notochord cell development
cell chemotaxis
branching involved in mammary gland duct morphogenesis
lens fiber cell morphogenesis
regulation of ERK1 and ERK2 cascade
response to growth factor
protein localization to plasma membrane
activation of GTPase activity
negative regulation of lymphangiogenesis
positive regulation of protein localization to plasma membrane
positive regulation of bicellular tight junction assembly
pericyte cell differentiation
protein phosphorylation
phosphorylation
peptidyl-tyrosine phosphorylation
neuron differentiation
protein kinase B signaling
negative regulation of protein kinase B signaling
positive regulation of establishment of protein localization to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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