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Product Details
PA5-111626
| Applications | Tested Dilution | Publications |
|---|---|---|
Immunohistochemistry (Paraffin) (IHC (P)) |
1:2,500-1:5,000 | - |
Immunocytochemistry (ICC/IF) |
0.25-2 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant Protein corresonding to Human EphB1 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.2, with 40% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2857036 |
Product Specific Information
Immunogen sequence: TCKPGYEPEN SVACKACPAG TFKASQEAEG CSHCPSNSRS PAEASPICTC RTGYYRADFD PPEVACTSVP SGPRNVISIV NE
Target Information
ephB1, previously known as Elk(eph-like kinase), is a receptor tyrosine kinase of the highly tissue restricted family of eph proteins. EphB1 and other ephB family members are type 1 membrane spanning proteins, comprised of immunoglobulin, fibronectin type III, and cysteine rich subdomains in the ecto domain, and the single uninterrupted cytoplasmic tyrosine kinase domain upstream of a carboxyterminal sterile alpha motif (SAM) domain. ephB family proteins bind ephrins of the B class, ligands that are also transmembrane spanning proteins capable of transmitting signals. ephB1 is expressed predominantly in developing neural structures in embryos, and in vascular epithelium of kidney, and other tissues. Upon binding to alternatively oligomerized ephrin B1, ephB1 signals regulation of cell attachment and cellcell assembly. Members of this protein family are implicated in neuronal and vascular cell targeting.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAPB; DRT; EK6; ELK; EPH tyrosine kinase 2; EPH-like kinase 6; EPHB3; Ephrin B1; Ephrin B2; Ephrin B3; Ephrin B4; Ephrin type-B receptor 1; EphrinB1; EphrinB2; EphrinB3; EphrinB4; EPHT3; ETK2; FLJ37986; HEK-6; HEK2; Hek5; MGC87492; NET; Neuronally-expressed EPH-related tyrosine kinase; PCBC; soluble EPHB1 variant 1; Tyro5; TYRO6; Tyrosine-protein kinase receptor EPH-2
Gene Aliases: ELK; EPHB1; EPHT2; HEK6; NET
UniProt ID: (Human) P54762
Entrez Gene ID: (Human) 2047
Molecular Function:
transmembrane signal receptor
angiogenesis
immunological synapse formation
axon guidance
peptidyl-tyrosine phosphorylation
optic nerve morphogenesis
central nervous system projection neuron axonogenesis
neurogenesis
establishment of cell polarity
retinal ganglion cell axon guidance
cell-substrate adhesion
regulation of JNK cascade
protein autophosphorylation
ephrin receptor signaling pathway
camera-type eye morphogenesis
detection of temperature stimulus involved in sensory perception of pain
positive regulation of synapse assembly
cell chemotaxis
dendritic spine development
dendritic spine morphogenesis
neural precursor cell proliferation
regulation of ERK1 and ERK2 cascade
regulation of neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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