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|Tested species reactivity||Human , Mouse|
|Published species reactivity||Human , Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the C-terminal end of mouse ephrin-A1 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes a member of the ephrin family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The proangiogenic factor ephrin-A1 is up-regulated in radioresistant murine tumor by irradiation.
||Nojiri K,Iwakawa M,Ichikawa Y,Imadome K,Sakai M,Nakawatari M,Ishikawa K,Ishikawa A,Togo S,Tsujii H,Shimada H,Imai T||Experimental biology and medicine (Maywood, N.J.) (234:112)||2009|
Ephrin-A1 binding to CD4+ T lymphocytes stimulates migration and induces tyrosine phosphorylation of PYK2.
||Aasheim HC,Delabie J,Finne EF||Blood (105:2869)||2005|
Efl1, EFL1, AI325262, LERK-1, TNFAIP4, Eplg1, Lerk1, LERK1, B61, Epl1, ECKLG, EPLG1
TNF alpha-induced protein 4, eph-related receptor tyrosine kinase ligand 1, ephrin-A1, immediate early response protein B61, ligand of eph-related kinase 1, tumor necrosis factor alpha-induced protein 4, tumor necrosis factor, alpha-induced protein 4, EPH-related receptor tyrosine kinase ligand 1, B61, ECKLG, EFL1, EPLG1, LERK-1, LERK1, TNFAIP4, tumor necrosis factor, alpha-induced protein 4