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Invitrogen
Ephrin A1 Polyclonal Antibody
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Product Details
PA5-19397
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (KVTVSGKITHSP) corresponding to the internal amino acids of EFNA1 (aa 144-155).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with canine, human and porcine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
This gene encodes a member of the ephrin family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EFNA1; EPH-related receptor tyrosine kinase ligand 1; Ephrin-A1; epididymis secretory sperm binding protein; gastric cancer metastasis associated long noncoding RNA; Immediate early response protein B61; LERK-1; ligand of eph-related kinase 1; TNF alpha-induced protein 4; Tumor necrosis factor alpha-induced protein 4; tumor necrosis factor, alpha-induced protein 4; unnamed protein product
Gene Aliases: AI325262; B61; ECKLG; EFL1; EFNA1; Epgl1; Epl1; EPLG1; GMAN; LERK-1; LERK1; TNFAIP4
UniProt ID: (Human) P20827, (Mouse) P52793, (Rat) P97553
Entrez Gene ID: (Human) 1942, (Mouse) 13636, (Rat) 94268
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
aortic valve morphogenesis
mitral valve morphogenesis
endocardial cushion to mesenchymal transition involved in heart valve formation
cell-cell signaling
axon guidance
negative regulation of macromolecule metabolic process
negative regulation of epithelial to mesenchymal transition
notochord formation
cell migration
central nervous system neuron differentiation
regulation of cell adhesion mediated by integrin
substrate adhesion-dependent cell spreading
negative regulation of MAPK cascade
positive regulation of MAPK cascade
regulation of blood vessel endothelial cell migration
regulation of angiogenesis
ephrin receptor signaling pathway
regulation of peptidyl-tyrosine phosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
regulation of axonogenesis
protein stabilization
negative regulation of dendritic spine morphogenesis
regulation of biological quality
negative regulation of thymocyte apoptotic process
positive regulation of beta-amyloid formation
positive regulation of intracellular signal transduction
positive regulation of amyloid precursor protein catabolic process
negative regulation of proteolysis involved in cellular protein catabolic process
activation of MAPK activity
neuron differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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