Immunogen sequence: YRRRHRKHSP QHTTTLSLST LATPKRSGNN NGSEPSDIII PLRTADSVFC PHYEKVSGDY GHPVYIVQEM P
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EPH-related receptor tyrosine kinase ligand 5; Ephrin-B2; EPLG5; HTK ligand; HTK-L; HTKL; LERK-5; LERK5; ligand of eph-related kinase 5; MGC126226; MGC126227; MGC126228
Gene Aliases: EFNB2; EPLG5; Htk-L; HTKL; LERK5
UniProt ID: (Human) P52799
Entrez Gene ID: (Human) 1948