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Ephrin Receptor B2 Polyclonal Antibody

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Ephrin Receptor B2 Polyclonal Antibody

Product Details

EPHBR2-201AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 50-150 on mouse Ephrin BR2 protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

EPHB2 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Developmentally-regulated Eph-related tyrosine kinase; EFL6; EFNB3; EK5; ELK; ELK-related tyrosine kinase; EPH B2; EPH tyrosine kinase 3; EPH-like kinase 5; EPHB3; Ephrin B1; Ephrin B2; Ephrin B3; Ephrin B4; Ephrin type-B receptor 2; EphrinB1; EphrinB2; EphrinB3; EphrinB4; EPLG8; ETK2; HEK-6; HEK2; LERK8; MGC87492; NET; Neural kinase; Nuk receptor tyrosine kinase; protein-tyrosine kinase HEK5; Renal carcinoma antigen NY-REN-47; TYRO6; Tyrosine-protein kinase receptor EPH-3; Tyrosine-protein kinase receptor SEK-3; Tyrosine-protein kinase TYRO5; unnamed protein product

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Gene Aliases: BDPLT22; CAPB; Cek5; DRT; EK5; EPHB2; EPHT3; EPTH3; ERK; ETECK; HEK5; Nuk; PCBC; Prkm5; Qek5; RGD1564232; Sek3; TYRO5

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UniProt ID: (Human) P29323, (Mouse) P54763

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Entrez Gene ID: (Human) 2048, (Mouse) 13844, (Rat) 313633

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Function(s)
nucleotide binding beta-amyloid binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity transmembrane-ephrin receptor activity receptor binding protein binding ATP binding axon guidance receptor activity kinase activity transferase activity signaling receptor activity identical protein binding macromolecular complex binding receptor activity transferase activity, transferring phosphorus-containing groups molecular_function transmembrane signal receptor
Process(es)
cell morphogenesis angiogenesis urogenital system development positive regulation of immunoglobulin production negative regulation of cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway nervous system development axonogenesis axon guidance axonal fasciculation learning or memory learning organ morphogenesis positive regulation of gene expression phosphorylation peptidyl-tyrosine phosphorylation optic nerve morphogenesis hindbrain tangential cell migration central nervous system projection neuron axonogenesis corpus callosum development regulation of blood coagulation positive regulation of cell migration positive regulation of B cell proliferation retinal ganglion cell axon guidance positive regulation of synaptic plasticity positive regulation of tumor necrosis factor production B cell activation inner ear morphogenesis regulation of JAK-STAT cascade negative regulation of Ras protein signal transduction ephrin receptor signaling pathway regulation of neuronal synaptic plasticity positive regulation of long-term neuronal synaptic plasticity camera-type eye morphogenesis regulation of axonogenesis negative regulation of axonogenesis regulation of body fluid levels positive regulation of multicellular organismal process regulation of filopodium assembly regulation of synapse assembly positive regulation of synapse assembly palate development dendritic spine development dendritic spine morphogenesis positive regulation of dendritic spine morphogenesis negative regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide commissural neuron axon guidance postsynaptic membrane assembly neuron projection retraction vesicle-mediated intercellular transport tight junction assembly negative regulation of cytokine production involved in inflammatory response positive regulation of long-term synaptic potentiation negative regulation of glutamate receptor signaling pathway positive regulation of glutamate receptor signaling pathway positive regulation of protein localization to plasma membrane cellular response to beta-amyloid neuron projection maintenance positive regulation of protein localization to cell surface regulation of T-helper 17 type immune response regulation of autophagosome assembly regulation of behavioral fear response protein phosphorylation multicellular organism development biological_process
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