PA5-29358 targets Ezrin in IHC (P) and WB applications and shows reactivity with Human, mouse, and Rat samples.
The PA5-29358 immunogen is recombinant fragment corresponding to a region within amino acids 103 and 444 of Human Ezrin.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
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Protein Aliases: CVIL; CVL; Cytovillin; cytovillin 2; epididymis secretory protein Li 105; Ezrin; p81; VIL2; villin 2; villin 2 (ezrin); Villin-2
Gene Aliases: AW146364; CVIL; CVL; EZR; HEL-S-105; p81; R75297; VIL2