Immunogen sequence: RLQDYEEKTK KAERELSEQI QRALQLEEER KRAQEEAERL EADRMAALRA KEELERQAVD QIKSQEQLAA ELAEYTAKIA LLEEARRRKE DEVEEWQHRA KEAQDDLVKT KEELHLVMTA P; Positive Samples: M21, SW480, U-251MG, 293T, Mouse intestine, Mouse brain, Rat brain; Cellular Location: Apical cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cell cortex, cytoskeleton, microvillus membrane, ruffle membrane
Ezrin serves as a tyrosine kinas substrate and is phosphorylated in EGF-stimulated cells. It is a cytoplasmic protein enriched in microvilli and other cell surfaces. Ezrin has an actin-binding capacity and is expressed in epithelial cells but not in mesenchymal cells. It is also expressed by certain epithelial tumors, such as renal cell adenocarcinomas.
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Protein Aliases: Cytovillin; cytovillin 2; epididymis secretory protein Li 105; Ezrin; p81; villin 2; villin 2 (ezrin); Villin-2
Gene Aliases: AW146364; CVIL; CVL; EZR; HEL-S-105; p81; R75297; VIL2