Immunogen sequence: RLQDYEEKTK KAERELSEQI QRALQLEEER KRAQEEAERL EADRMAALRA KEELERQAVD QIKSQEQLAA ELAEYTAKIA LLEEARRRKE DEVEEWQHRA KEAQDDLVKT KEELHLVMTA P; Positive Samples: M21, SW480, U-251MG, 293T, Mouse intestine, Mouse brain, Rat brain; Cellular Location: Apical cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cell cortex, cytoskeleton, microvillus membrane, ruffle membrane
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
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Protein Aliases: Cytovillin; cytovillin 2; DKFZp762H157; epididymis secretory protein Li 105; EZRI; Ezrin; FLJ26216; MGC1584; p81; villin 2; villin 2 (ezrin); Villin-2
Gene Aliases: AW146364; CVIL; CVL; EZR; HEL-S-105; p81; R75297; VIL2