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Invitrogen
Ezrin Recombinant Rabbit Monoclonal Antibody (1L5O2)
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FIGURE: 1 / 4
Ezrin Antibody (MA5-35229) in IHC (P)
Immunohistochemistry analysis of Ezrin in paraffin-embedded human colon carcinoma. Samples were incubated with Ezrin Monoclonal antibody (Product # MA5-35229) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
MA5-35229
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1L5O2
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human Ezrin (P15311)
Conjugate
Form
Liquid
Concentration
0.73 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IEVQQMKAQA REEKHQKQLE RQQLETEKKR RETVEREKEQ MMREKEELML RLQDYEEKTK KAERELSEQI QRALQLEEER KRAQEEAERL EADRMAALRA K
Target Information
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cytovillin; cytovillin 2; DKFZp762H157; epididymis secretory protein Li 105; EZRI; Ezrin; FLJ26216; MGC1584; p81; villin 2 (ezrin); Villin-2
Gene Aliases: CVIL; CVL; EZR; HEL-S-105; VIL2
UniProt ID: (Human) P15311
Entrez Gene ID: (Human) 7430
actin binding
protein binding
microtubule binding
protein domain specific binding
protein kinase A catalytic subunit binding
protein kinase A regulatory subunit binding
S100 protein binding
poly(A) RNA binding
cell adhesion molecule binding
actin filament binding
ATPase binding
cadherin binding involved in cell-cell adhesion
actin or actin-binding cytoskeletal protein
negative regulation of transcription from RNA polymerase II promoter
intestinal D-glucose absorption
sphingosine-1-phosphate signaling pathway
cytoskeletal anchoring at plasma membrane
leukocyte cell-cell adhesion
axon guidance
regulation of cell shape
regulation of cell size
positive regulation of gene expression
protein kinase A signaling
gland morphogenesis
membrane to membrane docking
microvillus assembly
astral microtubule organization
actin cytoskeleton reorganization
receptor internalization
regulation of microvillus length
regulation of actin cytoskeleton organization
cellular protein complex localization
positive regulation of multicellular organism growth
cortical microtubule organization
establishment of epithelial cell apical/basal polarity
filopodium assembly
phosphatidylinositol-mediated signaling
positive regulation of protein secretion
negative regulation of T cell receptor signaling pathway
actin filament bundle assembly
establishment of centrosome localization
establishment of endothelial barrier
negative regulation of ERK1 and ERK2 cascade
cellular response to cAMP
protein localization to cell cortex
establishment of protein localization to plasma membrane
positive regulation of establishment of protein localization to plasma membrane
negative regulation of interleukin-2 secretion
regulation of NIK/NF-kappaB signaling
regulation of organelle assembly
terminal web assembly
positive regulation of protein localization to early endosome
positive regulation of cellular protein catabolic process
negative regulation of p38MAPK cascade
positive regulation of early endosome to late endosome transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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