Immunogen sequence: NDRENYDIIK TYHYLYLAML ERFQDGDNIL EKEVLPPIHA YGNRTECRNP QELESIRQDR DALHMEGLIV RERILGADNI DVSHPIIY
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha and FEM1-b. F1Aalpha/FEM1-b is the homologue of C. elegans sex determining protein FEM-1. FEM-1/F1Aalpha is cleaved by CED-3 and caspase. FEM-1/F1Aalpha associates with CED-4 and its mammalian homologue Apaf-1. Overexpression of F1Aalpha induces apoptosis. F1Aalpha is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aalpha is expressed in a variety of human and mouse tissues.
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Protein Aliases: F1A-alpha; F1A-ALPHA, FIAA; FEM-1-like death receptor binding protein; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; FEM1-beta; FEM1b; Protein fem-1 homolog B
Gene Aliases: F1A-ALPHA; F1AA; FEM1-beta; FEM1B; KIAA0396
UniProt ID: (Human) Q9UK73
Entrez Gene ID: (Human) 10116