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Proteintech
F2 Polyclonal Antibody
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Product Details
24295-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
F2 Fusion Protein Ag18385 (273-622 aa encoded by BC051332)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: WCYVAGKPG DFGYCDLNYC EEAVEEETGD GLDEDSDRAI EGRTATSEYQ TFFNPRTFGS GEADCGLRPL FEKKSLEDKT ERELLESYID GRIVEGSDAE IGMSPWQVML FRKSPQELLC GASLISDRWV LTAAHCLLYP PWDKNFTEND LLVRIGKHSR TRYERNIEKI SMLEKIYIHP RYNWRENLDR DIALMKLKKP VAFSDYIHPV CLPDRETAAS LLQAGYKGRV TGWGNLKETW TANVGKGQPS VLQVVNLPIV ERPVCKDSTR IRITDNMFCA GYKPDEGKRG DACEGDSGGP FVMKSPFNNR WYQMGIVSWG EGCDRDGKYG FYTHVFRLKK WIQKVIDQFG E (273-622 aa encoded by BC051332)
Target Information
Prothrombin or Coagulation factor II, is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Coagulation factor II; coagulation factor II (thrombin); prepro-coagulation factor II; Prothrombin; prothrombin B-chain; serine protease
Gene Aliases: F2; PT; RPRGL2; THPH1
UniProt ID: (Human) P00734
Entrez Gene ID: (Human) 2147
positive regulation of protein phosphorylation
signal peptide processing
proteolysis
ER to Golgi vesicle-mediated transport
acute-phase response
cell surface receptor signaling pathway
multicellular organism development
blood coagulation
blood coagulation, intrinsic pathway
positive regulation of cell proliferation
regulation of cell shape
response to wounding
regulation of gene expression
negative regulation of platelet activation
positive regulation of phosphatidylinositol 3-kinase signaling
response to inactivity
peptidyl-glutamic acid carboxylation
platelet activation
regulation of blood coagulation
positive regulation of blood coagulation
positive regulation of cell growth
positive regulation of collagen biosynthetic process
fibrinolysis
cellular protein metabolic process
negative regulation of proteolysis
negative regulation of astrocyte differentiation
leukocyte migration
positive regulation of release of sequestered calcium ion into cytosol
regulation of cytosolic calcium ion concentration
negative regulation of fibrinolysis
cellular response to mechanical stimulus
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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