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F2 Polyclonal Antibody, MaxPab™

View all (26) Prothrombin antibodies

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F2 Polyclonal Antibody, MaxPab™

Product Details

H00002147-D01P

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

F2 (NP_000497.1, 1 a.a. approximately 622 a.a) full-length human protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MAHVRGLQLP GCLALAALCS LVHSQHVFLA PQQARSLLQR VRRANTFLEE VRKGNLEREC VEETCSYEEA FEALESSTAT DVFWAKYTAC ETARTPRDKL AACLEGNCAE GLGTNYRGHV NITRSGIECQ LWRSRYPHKP EINSTTHPGA DLQENFCRNP DSSTTGPWCY TTDPTVRRQE CSIPVCGQDQ VTVAMTPRSE GSSVNLSPPL EQCVPDRGQQ YQGRLAVTTH GLPCLAWASA QAKALSKHQD FNSAVQLVEN FCRNPDGDEE GVWCYVAGKP GDFGYCDLNY CEEAVEEETG DGLDEDSDRA IEGRTATSEY QTFFNPRTFG SGEADCGLRP LFEKKSLEDK TERELLESYI DGRIVEGSDA EIGMSPWQVM LFRKSPQELL CGASLISDRW VLTAAHCLLY PPWDKNFTEN DLLVRIGKHS RTRYERNIEK ISMLEKIYIH PRYNWRENLD RDIALMKLKK PVAFSDYIHP VCLPDRETAA SLLQAGYKGR VTGWGNLKET WTANVGKGQP SVLQVVNLPI VERPVCKDST RIRITDNMFC AGYKPDEGKR GDACEGDSGG PFVMKSPFNN RWYQMGIVSW GEGCDRDGKY GFYTHVFRLK KWIQKVIDQF GE

Target Information

Prothrombin or Coagulation factor II, is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Coagulation factor II; prepro-coagulation factor II; Prothrombin; prothrombin B-chain; thrombin factor II; thrombin precursor; unnamed protein product

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Gene Aliases: F2; PT; RPRGL2; THPH1

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UniProt ID: (Human) P00734

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Entrez Gene ID: (Human) 2147

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Function(s)
lipopolysaccharide binding endopeptidase activity serine-type endopeptidase activity receptor binding calcium ion binding protein binding growth factor activity heparin binding peptidase activity serine-type peptidase activity hydrolase activity receptor agonist activity thrombospondin receptor activity
Process(es)
proteolysis acute-phase response cell surface receptor signaling pathway G-protein coupled receptor signaling pathway blood coagulation hemostasis positive regulation of cell proliferation regulation of cell shape response to wounding regulation of gene expression negative regulation of platelet activation platelet activation regulation of blood coagulation positive regulation of blood coagulation negative regulation of blood coagulation positive regulation of cell growth positive regulation of insulin secretion positive regulation of collagen biosynthetic process fibrinolysis negative regulation of proteolysis positive regulation of JAK-STAT cascade negative regulation of astrocyte differentiation regulation of body fluid levels positive regulation of release of sequestered calcium ion into cytosol regulation of cytosolic calcium ion concentration cytolysis by host of symbiont cells positive regulation of protein kinase B signaling negative regulation of fibrinolysis antimicrobial humoral immune response mediated by antimicrobial peptide thrombin receptor signaling pathway neutrophil mediated killing of gram-negative bacterium negative regulation of cytokine production involved in inflammatory response positive regulation of protein localization to nucleus positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway ligand-gated ion channel signaling pathway positive regulation of reactive oxygen species metabolic process
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