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Invitrogen
F7 Polyclonal Antibody
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FIGURE: 1 / 1
F7 Antibody (PA5-109703) in WB
Western blot analysis of F7 in extracts of various cell lines. Samples were incubated with F7 Polyclonal antibody (Product # PA5-109703) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-109703
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 240-400 of human F7 (NP_062562.1).
Conjugate
Form
Liquid
Concentration
2.86 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RNLIAVLGEH DLSEHDGDEQ SRRVAQVIIP STYVPGTTNH DIALLRLHQP VVLTDHVVPL CLPERTFSER TLAFVRFSLV SGWGQLLDRG ATALELMVLN VPRLMTQDCL QQSRKVGDSP NITEYMFCAG YSDGSKDSCK GDSGGPHATH YRGTWYLTGI V
Target Information
Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in F7 production can cause coagulopathy.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coagulation factor VII; coagulation factor VII (serum prothrombin conversion accelerator); eptacog alfa; Factor 7; Factor7; FVII coagulation protein; Proconvertin; Serum prothrombin conversion accelerator; SPCA
Gene Aliases: AI132620; Cf7; F7; FVII; SPCA
UniProt ID: (Mouse) P70375, (Human) P08709, (Rat) Q8K3U6
Entrez Gene ID: (Mouse) 14068, (Human) 2155, (Rat) 260320
positive regulation of leukocyte chemotaxis
signal peptide processing
ER to Golgi vesicle-mediated transport
blood coagulation
blood coagulation, extrinsic pathway
circadian rhythm
positive regulation of platelet-derived growth factor receptor signaling pathway
response to organic cyclic compound
protein processing
peptidyl-glutamic acid carboxylation
positive regulation of blood coagulation
positive regulation of cell migration
organ regeneration
response to vitamin K
response to estrogen
positive regulation of positive chemotaxis
positive regulation of protein kinase B signaling
response to growth hormone
proteolysis
response to hormone
response to nutrient levels
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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