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FABP3 Polyclonal Antibody

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Antibody Testing Data (24)

FABP3 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 24

FABP3 Antibody (10676-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed MCF-7 cells using 10676-1-AP (FABP3 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

FABP3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

10676-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 13 publications 13 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 6 publications 6 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FABP3 Fusion Protein Ag1069 (1-133 aa encoded by BC007021)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MVDAFLGTW KLVDSKNFDD YMKSLGVGFA TRQVASMTKP TTIIEKNGDI LTLKTHSTFK NTEISFKLGV EFDETTADDR KVKSIVTLDG GKLVHLQKWD GQETTLVREL IDGKLILTLT HGTAVCTRTY EKEA (1-133 aa encoded by BC007021)

Target Information

Fatty acid binding proteins (FABP) are small (approximately 13-14 kDa) intracellular proteins with a high degree of tissue specificity. FABPs are a class of cytoplasmic proteins that bind long chain fatty acids. They are abundantly present in various cell types and seem to play an important role in the intracellular utilization of fatty acids. There are at least six distinct types of FABP, each showing a specific pattern of tissue expression. FABP leaks, due to its small size, rapidly out of is chemically damaged dying cells leading to a rise in serum levels. Liver FABP is a sensitive marker for cell damage of liver cells in vitro and in vivo. Is chemically damaged tissues are characterized histologically by absence (or low presence) of FABP facilitating recognition of such areas. Next to this L FABP is a marker for rapid hepatocyte lysis in vitro (as for example in toxicology assays) and for detection of liver damage during and after transplantation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

α-Synuclein decoy peptide protects mice against α-synuclein-induced memory loss.

CNS neuroscience & therapeutics

Guo Q,Kawahata I,Jia W,Wang H,Cheng A,Yabuki Y,Shioda N,Fukunaga K

Thu Jun 01 00:00:00 EDT 2023

Decreased Imiquimod-Induced Psoriasis-Like Skin Inflammation in a Novel Mvd^F250S/+ Knock-In Mouse Model.

Inflammation

La Y,Wong W,Peng K,Tian Z,Pan J,Sun R,Luan J,Yan K,Zhang Q,Zhang Z

Tue Aug 01 00:00:00 EDT 2023

Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice.

Journal of pharmacological sciences

Wang H,Fukunaga K,Cheng A,Wang Y,Arimura N,Yoshino H,Sasaki T,Kawahata I

Mon May 01 00:00:00 EDT 2023

Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice.

Journal of pharmacological sciences

Wang H,Fukunaga K,Cheng A,Wang Y,Arimura N,Yoshino H,Sasaki T,Kawahata I

Mon May 01 00:00:00 EDT 2023

Amelioration of Nicotine-Induced Conditioned Place Preference Behaviors in Mice by an FABP3 Inhibitor.

International journal of molecular sciences

Jia W,Kawahata I,Cheng A,Sasaki T,Sasaoka T,Fukunaga K

Sun Apr 02 00:00:00 EDT 2023

Fatty acid metabolism is involved in both retinal physiology and the pathology of retinal vascular diseases.

Prostaglandins, leukotrienes, and essential fatty acids

Umetsu A,Furuhashi M,Watanabe M,Ohkawa E,Tsugeno Y,Suzuki S,Itoh K,Ida Y,Hikage F,Ohguro H

Mon Aug 01 00:00:00 EDT 2022

Exploring the Multi-Tissue Crosstalk Relevant to Insulin Resistance Through Network-Based Analysis.

Frontiers in endocrinology

Yang L,Yang L,Wang X,Xing H,Zhao H,Xing Y,Zhou F,Wang C,Song G,Ma H

Wed Mar 09 00:00:00 EST 2022

Fatty Acid-Binding Protein 3 Expression in the Brain and Skin in Human Synucleinopathies.

Frontiers in aging neuroscience

Oizumi H,Yamasaki K,Suzuki H,Hasegawa T,Sugimura Y,Baba T,Fukunaga K,Takeda A

Tue Apr 13 00:00:00 EDT 2021

MMP-12 siRNA improves the homeostasis of the small intestine and metabolic dysfunction in high-fat diet feeding-induced obese mice.

Biomaterials

Song M,Zhang S,Tao Z,Li J,Shi Y,Xiong Y,Zhang W,Liu C,Chen S

Mon Nov 01 00:00:00 EDT 2021

Stomach secretes estrogen in response to the blood triglyceride levels.

Communications biology

Ito T,Yamamoto Y,Yamagishi N,Kanai Y

Tue Dec 07 00:00:00 EST 2021

Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure.

Cell death & disease

Wu D,Jian C,Peng Q,Hou T,Wu K,Shang B,Zhao M,Wang Y,Zheng W,Ma Q,Li CY,Cheng H,Wang X,Zhao L

Thu Mar 12 00:00:00 EDT 2020

Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization.

Brain research

Cheng A,Shinoda Y,Yamamoto T,Miyachi H,Fukunaga K

Fri Mar 15 00:00:00 EDT 2019

Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization.

Brain research

Cheng A,Shinoda Y,Yamamoto T,Miyachi H,Fukunaga K

Fri Mar 15 00:00:00 EDT 2019

Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization.

Brain research

Cheng A,Shinoda Y,Yamamoto T,Miyachi H,Fukunaga K

Fri Mar 15 00:00:00 EDT 2019

Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization.

Brain research

Cheng A,Shinoda Y,Yamamoto T,Miyachi H,Fukunaga K

Fri Mar 15 00:00:00 EDT 2019

Downregulations of placental fatty acid transporters during cadmium-induced fetal growth restriction.

Toxicology

Xu P,Guo H,Wang H,Lee SC,Liu M,Pan Y,Zheng J,Zheng K,Wang H,Xie Y,Bai X,Liu Y,Zhao M,Wang L

Mon Jul 01 00:00:00 EDT 2019

FABP3 in the Anterior Cingulate Cortex Modulates the Methylation Status of the Glutamic Acid Decarboxylase₆₇ Promoter Region.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Yamamoto Y,Kida H,Kagawa Y,Yasumoto Y,Miyazaki H,Islam A,Ogata M,Yanagawa Y,Mitsushima D,Fukunaga K,Owada Y

Wed Dec 05 00:00:00 EST 2018

FABP3 in the Anterior Cingulate Cortex Modulates the Methylation Status of the Glutamic Acid Decarboxylase₆₇ Promoter Region.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Yamamoto Y,Kida H,Kagawa Y,Yasumoto Y,Miyazaki H,Islam A,Ogata M,Yanagawa Y,Mitsushima D,Fukunaga K,Owada Y

Wed Dec 05 00:00:00 EST 2018

Aberrant fatty acid metabolism in skeletal muscle contributes to insulin resistance in zinc transporter 7 (znt7)-knockout mice.

The Journal of biological chemistry

Huang L,Tepaamorndech S,Kirschke CP,Newman JW,Keyes WR,Pedersen TL,Dumnil J

Fri May 18 00:00:00 EDT 2018

Aberrant fatty acid metabolism in skeletal muscle contributes to insulin resistance in zinc transporter 7 (znt7)-knockout mice.

The Journal of biological chemistry

Huang L,Tepaamorndech S,Kirschke CP,Newman JW,Keyes WR,Pedersen TL,Dumnil J

Fri May 18 00:00:00 EDT 2018

Malathion increases apoptotic cell death by inducing lysosomal membrane permeabilization in N2a neuroblastoma cells: a model for neurodegeneration in Alzheimer's disease.

Cell death discovery

Venkatesan R,Park YU,Ji E,Yeo EJ,Kim SY

Thu Oct 01 00:00:00 EDT 2020

Malathion increases apoptotic cell death by inducing lysosomal membrane permeabilization in N2a neuroblastoma cells: a model for neurodegeneration in Alzheimer's disease.

Cell death discovery

Venkatesan R,Park YU,Ji E,Yeo EJ,Kim SY

Thu Oct 01 00:00:00 EDT 2020

FABP3 protein promotes α-synuclein oligomerization associated with 1-methyl-1,2,3,6-tetrahydropiridine-induced neurotoxicity.

The Journal of biological chemistry

Shioda N,Yabuki Y,Kobayashi Y,Onozato M,Owada Y,Fukunaga K

Fri Jul 04 00:00:00 EDT 2014

FABP3 protein promotes α-synuclein oligomerization associated with 1-methyl-1,2,3,6-tetrahydropiridine-induced neurotoxicity.

The Journal of biological chemistry

Shioda N,Yabuki Y,Kobayashi Y,Onozato M,Owada Y,Fukunaga K

Fri Jul 04 00:00:00 EDT 2014

FABP3 protein promotes α-synuclein oligomerization associated with 1-methyl-1,2,3,6-tetrahydropiridine-induced neurotoxicity.

The Journal of biological chemistry

Shioda N,Yabuki Y,Kobayashi Y,Onozato M,Owada Y,Fukunaga K

Fri Jul 04 00:00:00 EDT 2014

FABP3 protein promotes α-synuclein oligomerization associated with 1-methyl-1,2,3,6-tetrahydropiridine-induced neurotoxicity.

The Journal of biological chemistry

Shioda N,Yabuki Y,Kobayashi Y,Onozato M,Owada Y,Fukunaga K

Fri Jul 04 00:00:00 EDT 2014

Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity.

Journal of cellular and molecular medicine

Xi L,Zhu SG,Hobbs DC,Kukreja RC

Tue Nov 01 00:00:00 EDT 2011

Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity.

Journal of cellular and molecular medicine

Xi L,Zhu SG,Hobbs DC,Kukreja RC

Tue Nov 01 00:00:00 EDT 2011

Bioinformatics

Protein Aliases: 422 protein; Cardiac Fatty Acid Binding Protein; FABP 3; fatty acid binding protein 11; Fatty acid binding protein 11 (FABP11); Fatty acid binding protein 3 heart; fatty acid binding protein 3, muscle and heart; Fatty acid binding protein heart; fatty acid binding protein heart 1; fatty acid binding protein heart 4; Fatty acid-binding protein 3; Fatty acid-binding protein, heart; H-FABP; heart FABP; heart fatty acid binding protein; Heart type fatty acid binding protein; Heart-type fatty acid-binding protein; M FABP; M-FABP; Mammary derived growth inhibitor; Mammary-derived growth inhibitor; MDGI; muscle and heart (mammary derived growth inhibitor); Muscle fatty acid binding protein; Muscle fatty acid-binding protein; Muscle O-FABP; Mylein protein P2 homolog / adopocyte

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Gene Aliases: FABP11; FABP3; Fabph-1; Fabph-4; Fabph1; Fabph4; H-FABP; M-FABP; MDGI; O-FABP

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UniProt ID: (Human) P05413, (Mouse) P11404, (Rat) P07483

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Entrez Gene ID: (Human) 2170, (Mouse) 14077, (Rat) 79131

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Function(s)

long-chain fatty acid transporter activity protein binding cytoskeletal protein binding long-chain fatty acid binding icosatetraenoic acid binding oleic acid binding transporter activity fatty acid binding lipid binding

Process(es)

fatty acid metabolic process negative regulation of cell proliferation long-chain fatty acid transport triglyceride catabolic process response to insulin response to drug cholesterol homeostasis long-chain fatty acid import regulation of fatty acid oxidation phospholipid homeostasis response to fatty acid positive regulation of phospholipid biosynthetic process transport regulation of phosphatidylcholine biosynthetic process fatty acid beta-oxidation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FABP3 Polyclonal Antibody

FABP3 Antibody (10676-1-AP) in ICC/IF

Product Details

10676-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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