The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; Mediator of receptor induced toxicity; MGC8528; protein FADD
Gene Aliases: Fadd; Mort1; Mort1/FADD
UniProt ID: (Mouse) Q61160
Entrez Gene ID: (Mouse) 14082