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Immunogen sequence: ISQDDSEITQ MEHNLASRRS SDDCHDHQTT PSLGVRTIEI KPSNKDPFSG ENITVKLGPW TELRQEEILV DNLLPNFESL ESNGKSKS
Highest antigen sequence identity to the following orthologs: Mouse - 67%, Rat - 64%.
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: family with sequence similarity 135, member A; FLJ20176; Protein FAM135A
Gene Aliases: FAM135A; KIAA1411
UniProt ID: (Human) Q9P2D6
Entrez Gene ID: (Human) 57579
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