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Proteintech
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Sequence of this protein is as follows: MGSLSGLRLA AGSCFRLCER DVSSSLRLTR SSDLKRINGF CTKPQESPGV PSRTYNRVPL HKPTDWQKKI LIWSGRFKKE DEIPETVSLE MLDAAKNKMR VKISYLMIAL TVVGCIFMVI EGKKAAQRHE TLTSLNLEKK ARLKEEAAMK AKTE
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E2-induced gene 5 protein; f162; growth and transformation-dependent protein; HIF-1 alpha-responsive proapoptotic molecule; S863-1-1; unnamed protein product
Gene Aliases: C3orf28; E2IG5; HGTD-P
UniProt ID: (Human) Q96A26
Entrez Gene ID: (Human) 26355
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