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Search Thermo Fisher Scientific
Immunogen sequence: YDYASKVNE ESLDRILKDR RKKVIGWYRF RRNTQQQMSY REQVLHKQLT RILGVPDLVF LLFSFISTAN NSTHALEYVL FRPNRRYNQR ISLAIPNLGN TSQQEYKVSS VPNTSQSYAK VIKEHGTDFF DKDGVMKDIR AIYQVYNALQ EKVQAVCADV EKSERVVESC QAEVNKLRRQ ITQRKNEKEQ ERRLQQAVLS RQMPSESLDP AFSPRMPSSG FAAEGRSTLG DAEASDPPPP YSDFHPNNQE STLSHSRMER SVFMPRPQAV GSSNYASTSA GLKYPGSGAD LPPPQRAAGD SGEDSDDSDY ENLIDPTEPS NSEYSHSKDS RPMAHPDEDP RNTQTSQI (69-415 aa encoded by BC008999 )
Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Abraxas brother; abraxas brother 1; Abraxas brother protein 1; BRISC complex subunit Abraxas 2; BRISC complex subunit Abro1; Em:AC068896.4; family with sequence similarity 175, member B; Protein FAM175B
Gene Aliases: AA589499; ABRAXAS2; ABRO1; AI853413; C430003P19Rik; FAM175B; KIAA0157
UniProt ID: (Human) B4DKR2, (Mouse) Q3TCJ1
Entrez Gene ID: (Human) 23172, (Mouse) 109359
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