This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: FTLDEVPKGK LHLRLEWLTL MPNASNLDKV LTDIKADKDQ ANDGLSSALL ILYLDSARNL PSGKKISSNP NPVVQMSVGH KAQESKIRYK TNEPVWEENF TFFIHNPKRQ DLEVEVRDEQ HQ
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 93%.
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: chr2 synaptotagmin; Chr2Syt; E-Syt2; extended synaptotagmin like protein 2; extended synaptotagmin protein 2; Extended synaptotagmin-2; extended synaptotagmin-like protein 2; family with sequence similarity 62 (C2 domain containing), member B
Gene Aliases: CHR2SYT; E-Syt2; ESYT2; FAM62B; KIAA1228
UniProt ID: (Human) A0FGR8
Entrez Gene ID: (Human) 57488