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Invitrogen
FAM84A Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-30705
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human FAM84A. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: IMR32.
Predicted reactivity: Human (99%), Mouse (95%), Rat (95%), Rhesus Monkey (99%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The FAM84A gene, also known as Family With Sequence Similarity 84 Member A, is located on chromosome 1q21.3. This gene encodes a protein that has been implicated in the development and progression of various cancers. In particular, FAM84A has been identified as a key player in the epithelial-mesenchymal transition (EMT) and Wnt/beta-catenin signaling pathways, which are crucial for tumor development and metastasis. Studies have shown that the downregulation of FAM84A can inhibit thyroid cancer progression while being negatively regulated by the tumor suppressor miR-874-3p. Additionally, FAM84A has been noted to be over-expressed in phenobarbital-promoted mouse liver tumors, indicating its potential role in chemical carcinogenesis. The gene's expression is regulated by nuclear receptor CAR, highlighting its involvement in liver cancer pathophysiology.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: family with sequence similarity 84 member A; neurologic sensory protein 1; neurological/sensory 1; protein FAM84A; unnamed protein product
Gene Aliases: FAM84A; NSE1; PP11517
UniProt ID: (Human) Q96KN4
Entrez Gene ID: (Human) 151354
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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