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Invitrogen
FANCD2 Polyclonal Antibody
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Product Details
PA5-120776
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
2.57 mg/mL
Amount
257 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: MCF7, HeLa, K-562, Jurkat, A-549. The target is usually found in the following locations: Nucleus.
Immunogen sequence: AFSKQNEASS HIQDDMHLVI RKQLSSTVFK YKLIGIIGAV TMAGIMAADR SESPSLTQER ANLSDEQCTQ VTSLLQLVHS CSEQSPQASA LYYDEFANLI QHEKLDPKAL EWVGHTICND FQDAFVVDSC VVPEGDFPFP VKALYGLEEY DTQDGIAINL LPLLFSQDFA KDGGPVTSQE S
Target Information
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin. Defects in the FANCD2 gene result in Fanconi anemia complementation group D2. This disorder affects all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp762A223; FACD2; Fanconi anemia complementation group D2; Fanconi anemia D2 protein; Fanconi anemia group D2 protein; Fanconi anemia group D2 protein homolog; FLJ23826; Protein FACD2; unnamed protein product
Gene Aliases: FA-D2; FA4; FACD; FAD; FAD2; FANCD; FANCD2
UniProt ID: (Human) Q9BXW9, (Rat) Q6IV68
Entrez Gene ID: (Human) 2177, (Rat) 312641
DNA repair
cellular response to DNA damage stimulus
synapsis
gamete generation
response to gamma radiation
intra-S DNA damage checkpoint
cellular response to oxidative stress
interstrand cross-link repair
regulation of regulatory T cell differentiation
brain morphogenesis
regulation of inflammatory response
neuronal stem cell population maintenance
double-strand break repair involved in meiotic recombination
regulation of CD40 signaling pathway
biological_process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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