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Invitrogen
FAP Monoclonal Antibody (F11-24), eBioscience™
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FIGURE: 1 / 3
FAP Antibody (BMS168) in Flow
Cancer science 2023 -
2 FIGURE Verification of fibroblast activation protein alpha (FAP-alpha) overexpression, and human and murine FAP-alpha cross-reactivity of AF3715. (A) Immunoblot analysis confirming FAP-alpha overexpression in 231-FAP and HT-1080-FAP cells. (B) Relative FAP-alpha mRNA expression levels (mean +- SD) of prostate cancer-associated fibroblasts (PCAFs), pancreatic cancer-associated fibroblasts (CAF35), MDA-MB-2... View More
Product Details
BMS168
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
C. elegans,
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
F11-24
Immunogen
Rec. Human FAP
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Description: BMS168 (F11-24) specifically reacts with Fibroblast Activation Protein (FAP), a cell surface glycoprotein of reactive human fibroblast. Among the normal adult organs tested BMS168 does not show immunoreactivity in immunohistological studies with either resting fibroblasts (fibrocytes) of the normal organ mesenchyme or the parenchymal cells. The single exception noted is a subset of endocrine cells in the pancreatic islets, presumably glucagon-producing A cells.
Applications Tested: Flow Cytometry, Immunohistochemistry, Immunoprecipitation.
Target Information
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 170 kDa melanoma membrane-bound gelatinase; Dipeptidyl peptidase FAP; FAPalpha; Fibroblast activation protein alpha; fibroblast activation protein, alpha; Gelatine degradation protease FAP; Integral membrane serine protease; Post-proline cleaving enzyme; Prolyl endopeptidase FAP; Seprase; Serine integral membrane protease; SIMP; Surface-expressed protease
Gene Aliases: DPPIV; FAP; FAPA; SIMP
UniProt ID: (Human) Q12884
Entrez Gene ID: (Human) 2191
angiogenesis
proteolysis
cell adhesion
regulation of collagen catabolic process
negative regulation of extracellular matrix disassembly
endothelial cell migration
proteolysis involved in cellular protein catabolic process
regulation of fibrinolysis
negative regulation of cell proliferation involved in contact inhibition
positive regulation of cell cycle arrest
mitotic cell cycle arrest
melanocyte proliferation
positive regulation of execution phase of apoptosis
melanocyte apoptotic process
negative regulation of extracellular matrix organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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