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Invitrogen
FASN Polyclonal Antibody
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FIGURE: 1 / 5
FASN Antibody (PA5-87440) in IHC (P)
Immunohistochemistry analysis of FASN in paraffin-embedded human gastric cancer. Samples were incubated with FASN Polyclonal antibody (Product # PA5-87440) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-87440
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 2212-2511 of human Fatty Acid Synthase (FASN) (NP_0040954)
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Amount
90 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QQQTQLNLRS LLVNPEGPTL MRLNSVQSSE RPLFLVHPIE GSTTVFHSLA SRLSIPTYGL QCTRAAPLDS IHSLAAYYID CIRQVQPEGP YRVAGYSYGA CVAFEMCSQL QAQQSPAPTH NSLFLFDGSP TYVLAYTQSY RAKLTPGCEA EAETEAICFF VQQFTDMEHN RVLEALLPLK GLEERVAAAV DLIIKSHQGL DRQELSFAAR SFYYKLRAAE QYTPKAKYHG NVMLLRAKTG GAYGEDLGAD YNLSQVCDGK VSVHVIEGDH RTLLEGSGLE SIISIIHSSL AEPRVSVREG; Positive Samples: H460; Cellular Location: Cytoplasm, Melanosome
Target Information
Fatty acid synthase is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; Acyl-[acyl-carrier-protein] hydrolase; encodes region of fatty acid synthase activity; FAS; multifunctional protein; Enoyl-[acyl-carrier-protein] reductase; FAS; Fatty acid synthase; MGC14367; MGC15706; short chain dehydrogenase/reductase family 27X, member 1; Type I fatty acid synthase
Gene Aliases: FAS; FASN; OA-519; SDR27X1
UniProt ID: (Human) P49327
Entrez Gene ID: (Human) 2194
RNA binding
catalytic activity
fatty acid synthase activity
[acyl-carrier-protein] S-acetyltransferase activity
[acyl-carrier-protein] S-malonyltransferase activity
3-oxoacyl-[acyl-carrier-protein] synthase activity
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
protein binding
acyl-[acyl-carrier-protein] hydrolase activity
oxidoreductase activity
transferase activity
transferase activity, transferring acyl groups
hydrolase activity
lyase activity
3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
phosphopantetheine binding
identical protein binding
cadherin binding
enoyl-[acyl-carrier-protein] reductase (NADPH) activity
osteoblast differentiation
epithelial cell development
acetyl-CoA metabolic process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
inflammatory response
response to nutrient
lipid biosynthetic process
ether lipid biosynthetic process
tissue development
neutrophil differentiation
monocyte differentiation
mammary gland development
response to nutrient levels
modulation by host of viral process
fatty-acyl-CoA biosynthetic process
response to caloric restriction
cellular response to interleukin-4
establishment of endothelial intestinal barrier
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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