FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by secretase to release intracellular domain (ICD). FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane associated guanylate kinase MPP5/PALS1. FAT4 is involved in the maintenance of PCP and inhibition of cell proliferation.
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Protein Aliases: Cadherin family member 14; cadherin-related family member 11; CDHF14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; FATJ; hFat4; Protocadherin Fat 4; putative protein product of Nbla00548
Gene Aliases: 6030410K14Rik; 9430004M15; CDHF14; CDHR11; FAT-J; FAT4; FATJ; HKLLS2; NBLA00548; VMLDS2