This antibody is predicted to react with bovine, porcine and rat based on sequence homology.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs , which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing of this gene results in two transcript variants encoding two isoforms of different sizes.
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Protein Aliases: atrogin 1; Atrogin-1; F-box only protein 32; F-box protein 32; Fbx32; FBXO32; FLJ32424; MAFbx; MGC33610; Muscle atrophy F-box protein
Gene Aliases: 4833442G10Rik; AI430017; ATROGIN1; Fbx32; FBXO32; Gm20361; MAFbx