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Rockland
FBXO4 Polyclonal Antibody
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Product Details
100-401-963
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This whole rabbit serum was prepared by repeated immunizations with a synthetic peptide derived from sequences unique to the N-terminus of FBX4 and conserved between the human and murine proteins (see link below for the full-length sequence of the mouse gene product).
Conjugate
Form
Liquid
Concentration
85 mg/mL
Amount
8.5 mg
Storage buffer
0.02M potassium phosphate/whole serum, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This antiserum is directed against human and mouse FBX4. Reactivity against homologues from other sources is not known.
Target Information
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: F-box only protein 4; F-box protein Fbx4; unnamed protein product
Gene Aliases: 1700096C12Rik; AI851261; AW494535; FBX4; FBXO4
UniProt ID: (Human) Q9UKT5, (Mouse) Q8CHQ0
Entrez Gene ID: (Human) 26272, (Mouse) 106052
protein polyubiquitination
telomere maintenance
ubiquitin-dependent protein catabolic process
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein ubiquitination
cytoplasmic translational initiation
regulation of macromolecule biosynthetic process
posttranscriptional regulation of gene expression
cellular homeostasis
regulation of protein stability
protein destabilization
positive regulation of telomere maintenance via telomerase
common myeloid progenitor cell proliferation
positive regulation of translation
negative regulation of fibroblast proliferation
cellular response to ionizing radiation
cellular senescence
membraneless organelle assembly
negative regulation of protein localization to nucleus
positive regulation of protein polyubiquitination
regulation of DNA damage checkpoint
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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