Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration. Plays a role in the regulation of neurotransmission at mature neurons. May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway. Specifically recognizes TP73, promoting its ubiquitination and degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: F-box only protein 45; F-box protein 45; F-box/SPRY domain-containing protein 1; fbxo45; hFbxo45; mFbxo45
Gene Aliases: 2610017J04Rik; AI463119; BC026799; FBX45; FBXO45; RGD1311861