F-box proteins, critical components of the conserved ubiquitin-protein ligase complex SCF (Skp1/Cdc53-Cullin1/F-box), recruit substrates for ubiquitination and consequent degradation through their specific protein-protein interaction domains. Novel human F-box proteins named FBG1, FBG2, FBG3, FBG4 and FBG5 constitute a subfamily of mammalian F-box proteins. FBG genes are expressed in a limited number of human tissues including kidney, liver, brain and muscle tissues.
Protein Aliases: Early mitotic inhibitor 1; f-box only protein 31; F-box only protein 5; F-box protein Fbx5; fbxo5
Gene Aliases: 2510044I10Rik; C85305; EMI1; FBX5; Fbxo31; FBXO5