Immunogen sequence: LSLSAVCRDL FTASNDPLLW RFLYLRDFRD NTVRVQDTDW KELYRKRHIQ RKESPKGRFV MLLPSSTHTI PFYPNPLHPR PFPSSRLPPG IIGGEYDQRP TLPYVGDPIS SLIPGPGETP SQFPPLRPRF DPVGPLPGPN PILPGRGGPN DRFPFRPSRG RPTDGRLSFM; Positive Samples: HepG2, Jurkat, Mouse testis, Mouse liver; Cellular Location: Cytoplasm, Mitochondrion, Nucleus, cytosol
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined.
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Protein Aliases: DKFZp686B08113; F-box only protein 7
Gene Aliases: 2410015K21Rik; A230052G17Rik; AI117679; AW260462; C85118; FBX; FBX07; FBX7; FBXO7; PARK15; PKPS