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Proteintech
FBXW11 Polyclonal Antibody
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Product Details
13149-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FBXW11 Fusion Protein Ag3761 (216-529 aa encoded by BC026213)
Conjugate
Form
Liquid
Concentration
0.16 mg/mL
Amount
24 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NLQRIQCRS ENSKGVYCLQ YDDEKIISGL RDNSIKIWDK TSLECLKVLT GHTGSVLCLQ YDERVIVTGS SDSTVRVWDV NTGEVLNTLI HHNEAVLHLR FSNGLMVTCS KDRSIAVWDM ASATDITLRR VLVGHRAAVN VVDFDDKYIV SASGDRTIKV WSTSTCEFVR TLNGHKRGIA CLQYRDRLVV SGSSDNTIRL WDIECGACLR VLEGHEELVR CIRFDNKRIV SGAYDGKIKV WDLQAALDPR APASTLCLRT LVEHSGRVFR LQFDEFQIIS SSHDDTILIW DFLNVPPSAQ NETRSPSRTY TYISR (216-529 aa encoded by BC026213)
Target Information
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: beta-transducin repeat-containing protein 2; F-box and WD repeats protein beta-TrCP2; F-box and WD-40 domain protein 11; F-box and WD-40 domain protein 1B; F-box protein Fbw1b; F-box/WD repeat-containing protein 11; F-box/WD repeat-containing protein 1B; Homologous to Slimb protein; HOS; unnamed protein product
Gene Aliases: 2310065A07Rik; AA536858; BTRC2; BTRCP2; Fbw11; FBW1B; FBXW11; FBXW1B; HOS; KIAA0696; NEDJED
UniProt ID: (Human) Q9UKB1, (Mouse) Q5SRY7
Entrez Gene ID: (Human) 23291, (Mouse) 103583
establishment of mitotic spindle orientation
protein polyubiquitination
protein dephosphorylation
nuclear migration
germ cell development
retrograde axonal transport
Wnt signaling pathway
protein ubiquitination
microtubule organizing center organization
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
protein destabilization
positive regulation of circadian rhythm
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of proteolysis
positive regulation of transcription, DNA-templated
vesicle transport along microtubule
rhythmic process
brain morphogenesis
cell cycle
negative regulation of NF-kappaB import into nucleus
negative regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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