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FCGR2B / CD32b Polyclonal Antibody

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FCGR2B / CD32b Polyclonal Antibody

Product Details

21541-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FCGR2B / CD32b Fusion Protein Ag16189 (254-310 aa encoded by BC031992)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Amount

40.5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ALPGYPECR EMGETLPEKP ANPTNPDEAD KVGAENTITY SLLMHPDALE EPDDQNRI (254-310 aa encoded by BC031992)

Target Information

This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD32; CD32 receptor 2; CD32 receptor 2a; CD32 receptor 2b; CD32A; CDw32; Fc fragment of IgG receptor IIb; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc gamma RIIb; fc-gamma RII-a; Fc-gamma RII-b; Fc-gamma RII-c; fc-gamma-RIIa; Fc-gamma-RIIb; Fc-gamma-RIIc; FcGR; FCGR2A1; FCGR2B; fcRII-a; fcRII-b; FGFR2B; IgG Fc fragment receptor; IgG Fc fragment receptor precursor; IgG Fc receptor beta-Fc-gamma-RII; IgG Fc receptor II-b; IgG Fc receptor II-c; Low affinity immunoglobulin gamma Fc region receptor II-b; Low affinity immunoglobulin gamma Fc region receptor II-c

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Gene Aliases: CD32; CD32B; FCG2; FcgammaRIIb; FCGR2; FCGR2B; FCGR2C; FcGRIIB; FcRII-c; IGFR2

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UniProt ID: (Human) P31994

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Entrez Gene ID: (Human) 2213

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Function(s)
beta-amyloid binding protein binding IgG receptor activity low-affinity IgG receptor activity IgG binding macromolecular complex binding
Process(es)
antibody-dependent cellular cytotoxicity negative regulation of type I hypersensitivity negative regulation of antibody-dependent cellular cytotoxicity negative regulation of cytokine production immune effector process follicular dendritic cell activation mature B cell differentiation involved in immune response follicular B cell differentiation immune complex clearance by monocytes and macrophages negative regulation of dendritic cell antigen processing and presentation regulation of B cell antigen processing and presentation negative regulation of immunoglobulin production regulation of immune system process regulation of adaptive immune response negative regulation of acute inflammatory response to antigenic stimulus positive regulation of humoral immune response negative regulation of humoral immune response mediated by circulating immunoglobulin receptor-mediated endocytosis phagocytosis phagocytosis, engulfment defense response inflammatory response cell surface receptor signaling pathway response to bacterium immunoglobulin mediated immune response antigen processing and presentation of exogenous peptide antigen via MHC class II cerebellum development negative regulation of B cell proliferation negative regulation of interleukin-10 production positive regulation of tumor necrosis factor production Fc-gamma receptor signaling pathway negative regulation of macrophage activation negative regulation of cytotoxic T cell degranulation regulation of innate immune response mast cell activation positive regulation of JNK cascade negative regulation of phagocytosis positive regulation of phagocytosis negative regulation of immune response negative regulation of B cell receptor signaling pathway negative regulation of B cell activation cellular response to molecule of bacterial origin regulation of immune complex clearance by monocytes and macrophages negative regulation of neutrophil activation regulation of dendritic spine maintenance regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway cellular response to beta-amyloid positive regulation of response to endoplasmic reticulum stress negative regulation of dendritic cell differentiation
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