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Invitrogen
FCRL3 Polyclonal Antibody
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FIGURE: 1 / 1
FCRL3 Antibody (PA5-120092) in WB
Western blot analysis of FCRL3 in extracts of various cell lines. Samples were incubated with FCRL3 Polyclonal antibody (Product # PA5-120092) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3s.
Product Details
PA5-120092
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 600-720 of human FCRL3 (NP_443171.2).
Conjugate
Form
Liquid
Concentration
1.92 mg/mL
Amount
192 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: Raji, B cells, 293T, U-937, Mouse kidney, Rat kidney. The target is usually found in the following locations: Cell membrane, Single-pass type I membrane protein.
Immunogen sequence: RRKPGGLSAT GTSSHSPSEC QEPSSSRPSR IDPQEPTHSK PLAPMELEPM YSNVNPGDSN PIYSQIWSIQ HTKENSANCP MMHQEHEELT VLYSELKKTH PDDSAGEASS RGRAHEEDDE E
Target Information
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD307c; Fc receptor homolog 3; Fc receptor-like protein 3; FcR-like protein 3; FcRH3; hIFGP3; IFGP family protein 3; Ig-like superfamily receptor; Ig-superfamily protein SPAP2a; Ig-superfamily protein SPAP2b; Ig-superfamily protein SPAP2c; Ig-superfamily protein SPAP2d; Ig-superfamily protein SPAP2e; Immune receptor translocation-associated protein 3; immunoglobulin superfamily receptor translocation associated protein 3; IRTA3; MAIA; SH2 domain-containing phosphatase anchor protein 2; unnamed protein product
Gene Aliases: CD307c; FCRH3; FCRL3; IFGP3; IRTA3; MAIA; SPAP2
UniProt ID: (Human) Q96P31
Entrez Gene ID: (Human) 115352
negative regulation of immunoglobulin production
immune response
cell surface receptor signaling pathway
single fertilization
positive regulation of B cell proliferation
regulation of toll-like receptor 9 signaling pathway
positive regulation of MAPK cascade
regulation of B cell differentiation
negative regulation of B cell receptor signaling pathway
regulation of B cell activation
regulation of calcium ion import
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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