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FDPS Polyclonal Antibody
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Product Details
BS-13153R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FDPS, amino acids 201-300.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes. 1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (2E,6E)-farnesyl diphosphate synthase; Cholesterol-regulated 39 kDa protein; CR 39; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; Farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; farnesyl pyrophosphate synthetase (EC 2.5.1.1); farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase; FPP synthase; FPP synthetase; FPS; Geranyltranstransferase; KIAA1293; testis-specific farnesyl pyrophosphate synthetase; unnamed protein product
Gene Aliases: 6030492I17Rik; Ac2-125; AI256750; FDPS; Fdpsl1; FPPS; FPS; KIAA1293; mKIAA1293; POROK9
UniProt ID: (Human) P14324, (Rat) P05369, (Mouse) Q920E5
Entrez Gene ID: (Human) 2224, (Rat) 83791, (Mouse) 110196
lipid metabolic process
steroid biosynthetic process
cholesterol biosynthetic process
steroid metabolic process
cholesterol metabolic process
isoprenoid biosynthetic process
sterol biosynthetic process
geranyl diphosphate biosynthetic process
farnesyl diphosphate biosynthetic process
spermatogenesis
male gonad development
response to testosterone
response to drug
response to peptide hormone
positive regulation of cholesterol biosynthetic process
positive regulation of cell growth involved in cardiac muscle cell development
response to cholesterol
cellular response to fatty acid
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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