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Invitrogen
FDPS Polyclonal Antibody
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FIGURE: 1 / 2
FDPS Antibody (PA5-103003) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded FDPS in human gastric tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with FDPS polyclonal antibody (Product # PA5-103003) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-103003
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human FDPS(Accession P14324), corresponding to amino acid residues F304-E354.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total FDPS.
Target Information
The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes. 1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (2E,6E)-farnesyl diphosphate synthase; cholesterol-regulated 39 kDa protein; cholesterol-regulated protein CR39; CR 39; dimethylallyltranstransferase; farnesyl diphosphate synthase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; farnesyl pyrophosphate synthetase; farnesyl pyrophosphate synthetase (EC 2.5.1.1); farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase; farnesyl-diphosphate synthase; Fdps; FPP synthase; FPP synthetase; FPS; geranyltranstransferase; KIAA1293; testis-specific farnesyl pyrophosphate synthetase; unnamed protein product
Gene Aliases: 6030492I17Rik; Ac2-125; Fdpsl1; FPPS; FPS; mKIAA1293; POROK9
UniProt ID: (Human) P14324, (Mouse) Q920E5, (Rat) P05369
Entrez Gene ID: (Human) 2224, (Mouse) 110196, (Rat) 83791
cholesterol biosynthetic process
isoprenoid biosynthetic process
farnesyl diphosphate biosynthetic process, mevalonate pathway
geranyl diphosphate biosynthetic process
geranylgeranyl diphosphate biosynthetic process
zymosterol biosynthetic process
farnesyl diphosphate biosynthetic process
positive regulation of cholesterol biosynthetic process
positive regulation of cell growth involved in cardiac muscle cell development
spermatogenesis
male gonad development
response to xenobiotic stimulus
response to testosterone
response to peptide hormone
response to cholesterol
cellular response to fatty acid
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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