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Product Details
PA5-28228
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 43 and 381 of Human FDPS
Conjugate
Form
Liquid
Concentration
1.75 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2545704
Product Specific Information
Recommended positive controls: A549, H1299, HCT116, Mouse brain, rat liver.
Predicted reactivity: Mouse (89%), Rat (89%), Pig (89%), Bovine (91%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes. 1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: (2E,6E)-farnesyl diphosphate synthase; Cholesterol-regulated 39 kDa protein; CR 39; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; Farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase; FPP synthase; FPP synthetase; FPS; Geranyltranstransferase; testis-specific farnesyl pyrophosphate synthetase
Gene Aliases: 6030492I17Rik; Ac2-125; AI256750; FDPS; Fdpsl1; FPPS; FPS; KIAA1293; mKIAA1293; POROK9
UniProt ID: (Human) P14324, (Rat) P05369, (Mouse) Q920E5
Entrez Gene ID: (Human) 2224, (Rat) 83791, (Mouse) 110196
cholesterol biosynthetic process
spermatogenesis
isoprenoid biosynthetic process
male gonad development
geranyl diphosphate biosynthetic process
response to testosterone
response to drug
response to peptide hormone
farnesyl diphosphate biosynthetic process
positive regulation of cholesterol biosynthetic process
positive regulation of cell growth involved in cardiac muscle cell development
response to cholesterol
cellular response to fatty acid
viral process
lipid metabolic process
steroid biosynthetic process
steroid metabolic process
cholesterol metabolic process
sterol biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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