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Invitrogen
FDPS Monoclonal Antibody (C1)
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FIGURE: 1 / 3
FDPS Antibody (MA5-51147) in IHC (P)
Immunohistochemistry (Paraffin) analysis of FDPS in rat liver tissue using FDPS Monoclonal Antibody (C1) (Product # MA5-51147) (30 µg/mL) and using PBS intead of the primary antibody as a control. The sample was then stained with HRP-Goat anti-Mouse IgG polyclonal secondary antibody (2 µg/mL). DAB staining.
Product Details
MA5-51147
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
C1
Immunogen
Recombinant Rat FDPS protein, Met1-Lys353 (Accession #P05369)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
200 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes. 1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (2E,6E)-farnesyl diphosphate synthase; Cholesterol-regulated 39 kDa protein; CR 39; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; Farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; FPP synthase; FPP synthetase; Geranyltranstransferase; testis-specific farnesyl pyrophosphate synthetase
Gene Aliases: Ac2-125; Fdps; FPS
UniProt ID: (Rat) P05369
Entrez Gene ID: (Rat) 83791
cholesterol biosynthetic process
spermatogenesis
isoprenoid biosynthetic process
male gonad development
geranyl diphosphate biosynthetic process
response to testosterone
response to drug
response to peptide hormone
farnesyl diphosphate biosynthetic process
positive regulation of cholesterol biosynthetic process
positive regulation of cell growth involved in cardiac muscle cell development
response to cholesterol
cellular response to fatty acid
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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