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FEM1A Polyclonal Antibody
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Product Details
BS-6861R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FEM1A, amino acids 258-360.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
FEM1A (FEM-1 homolog a), also known as EPRAP (Prostaglandin E receptor 4-associated protein), is a 669 amino acid cytoplasmic protein that belongs to the FEM-1 family. FEM1A is present in atheromata and in macrophages derived from peripheral blood monocytes. FEM1A may be a component of an E3 ubiquitin-protein ligase complex and functions as a substrate recognition subunit. It is suggested that FEM1A participates in anti-inflammatory signaling of macrophages via its interaction with EP4. FEM1A is down-regulated in Rhabdomyosarcoma, the most common soft tissue neoplasm of children. FEM1A is considered a candidate gene for polycystic ovary syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp762M136; FEM1-alpha; FEM1-alpha-A; FEM1a; FEM1a-A; feminization 1 homolog a; Prostaglandin E receptor 4-associated protein; Protein fem-1 homolog A; Protein fem-1 homolog A-A; unnamed protein product
Gene Aliases: AW611390; EPRAP; FEM1A; Fem1aa
UniProt ID: (Human) Q9BSK4, (Rat) Q4V890, (Mouse) Q9Z2G1
Entrez Gene ID: (Human) 55527, (Rat) 316131, (Mouse) 14154
protein ubiquitination
negative regulation of MAP kinase activity
negative regulation of inflammatory response
regulation of ubiquitin-protein transferase activity
MAPK cascade
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of inflammatory response
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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