Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
FER Fusion Protein Ag18173 (96-445 aa encoded by BC017060) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.43 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: PLHRLTMMI KDKQQVKKSY IGVHQQIEAE MIKVTKTELE KLKCSYRQLI KEMNSAKEKY KEALAKGKET EKAKERYDKA TMKLHMLHNQ YVLALKGAQL HQNQYYDITL PLLLDSLQKM QEEMIKALKG IFDEYSQITS LVTEEIVNVH KEIQMSVEQI DPSTEYNNFI DVHRTTAAKE QEIEFDTSLL EENENLQANE IMWNNLTAES LQVMLKTLAE ELMQTQQMLL NKEEAVLELE KRIEESSETC EKKSDIVLLL SQKQALEELK QSVQQLRCTE AKFSAQKELL EQKVQENDGK EPPPVVNYEE DARSVTSMER KERLSKFESI RHSIAGIIRS PKSALGSSAL S (96-445 aa encoded by BC017060)
Protein kinases constitute a large superfamily of enzymes with key regulatory functions in nearly all signal transmission processes of eukaryotic cells. FER is found in the cytoplasm and in the nucleus, where it was associated with the chromatin fraction. Its ubiquitous expression and its subcellular location indicate that it may be involved in key regulatory processes. The group IV cytoplasmic protein-tyrosine kinase Fer has been linked to cellular signaling responses to many different stimuli, including growth factors and cytokines. Data suggest a biological role for Fer in regulation of leukocyte recruitment during the innate immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 2.7.10.2; Feline encephalitis virus-related kinase FER; fer (fms/fps related) protein kinase, testis specific 2; fer (fps/fes related) tyrosine kinase; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; p94-Fer; phosphoprotein NCP94; protein phosphatase 1, regulatory subunit 74; Proto-oncogene c-Fer; proto-oncogene tyrosine-protein kinase Fer; Tyrosine kinase 3; Tyrosine-protein kinase Fer
Gene Aliases: AV082135; C330004K01Rik; FER; Fert; Fert2; p94-Fer; PPP1R74; TYK3
UniProt ID: (Human) P16591, (Mouse) Q6PEE5
Entrez Gene ID: (Human) 2241, (Mouse) 14158
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