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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 120-420 of human FES. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.19 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2807973 |
Immunogen sequence: WQQLQQELTK THSQDIEKLK SQYRALARDS AQAKRKYQEA SKDKDRDKAK DKYVRSLWKL FAHHNRYVLG VRAAQLHHQH HHQLLLPGLL RSLQDLHEEM ACILKEILQE YLEISSLVQD EVVAIHREMA AAAARIQPEA EYQGFLRQYG SAPDVPPCVT FDESLLEEGE PLEPGELQLN ELTVESVQHT LTSVTDELAV ATEMVFRRQE MVTQLQQELR NEEENTHPRE RVQLLGKRQV LQEALQGLQV ALCSQAKLQA QQELLQTKLE HLGPGEPPPV LLLQDDRHST SSSEQEREGG R; Positive Samples: Mouse heart, Mouse brain; Cellular Location: Cell junction, Cell membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus, Peripheral membrane protein, cytoskeleton, cytosol, focal adhesion
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 2.7.10.2; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog; feline sarcoma oncogene; Feline sarcoma/Fujinami avian sarcoma oncogene homolog; Oncogene FES, feline sarcoma virus; p93c-fes; Proto-oncogene c-Fes; Proto-oncogene c-Fps; proto-oncogene tyrosine-protein kinase Fes/Fps; tyrosine kinase Fps/Fes; Tyrosine-protein kinase Fes/Fps; Variant 4
Gene Aliases: AI586313; BB137047; c-fes; FES; FPS
UniProt ID: (Human) P07332, (Mouse) P16879
Entrez Gene ID: (Human) 2242, (Mouse) 14159
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