Immunogen sequence: MEAPLVSLDE EFEDLRPSCS EDPEEKPQCF YGSSPHHLED PSLSELENFS SEIISFKSME DLVNEFDEKL NVCFRNYNAK TENLAPVKNQ LQIQEEEETL QDEEVWDALT DNYIPSLSED WRDPNIEALN GNCSDTEIHE KEEEEFNEKS ENDSGINEEP; Positive Samples: Mouse brain, Rat brain; Cellular Location: Cell membrane, Cytoplasm, centrosome, cytoskeleton, microtubule organizing center
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.
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Protein Aliases: F37; Fasciculation and elongation protein zeta-1; protein kinase C-binding protein Zeta1; zygin 1; Zygin I; Zygin-1
Gene Aliases: Fez1; UNC-76; UNC76