PA1-25518 detects FGF10 from human samples.
PA1-25518 has been successfully used in neutralization, inhibition assays, and Western blot procedures. The predicted FGF10 molecular weight is 23 kDa. Neutralization: To yield one-half maximal inhibition (ND50), a 1.5 ng/mL concentration of Human FGF10 requires 0.20-0.35 µg/mL.
The PA1-25518 immunogen is highly purified recombinant human FGF10.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FGF-10; Fibroblast growth factor 10; Keratinocyte growth factor 2; produced by fibroblasts of urinary bladder lamina propria
Gene Aliases: FGF10
UniProt ID: (Human) O15520
Entrez Gene ID: (Human) 2255